Turning cancer resistance into vulnerability

Targeted Therapy for Relapsed & Refractory Cancers

We engineer small molecules designed to exploit metabolic vulnerabilities precisely when standard therapies fail.

Our Mission: Delivering cures for patients who have run out of options.

check_circleLead Program (ORT001): Acute Lymphoblastic Leukemia
check_circleTraction: High-efficacy preclinical data secured
check_circleStatus: Entering Seed Round to launch regulatory preclinical activities

They support us

i-Lab
SATTbpiIPCCarnot
ARCCanceropoleImpulseRISEIAEDeeptechOnco Start

Our Technology - A metabolic trap

Orthos Therapeutics Technology Infographic
Publication Reference

Cancer cells are addicted to proliferation and die when starved

Healthy cells simply pause and survive

Meet Our Complementary Team

Management Team

Guillaume Dubreuil - Co-founder & CEO

Guillaume Dubreuil

Co-founder & CEO

Guillaume Dubreuil

20+ years expertise inBusiness Development

Xavier Morelli - Co-founder & CSO

Xavier Morelli

Co-founder & CSO

Xavier Morelli

CNRS Research Director (DRCE)25+ years expertise in Drug Discovery

Didier Pez - Co-founder & COO

Didier Pez

Co-founder & COO

Didier Pez

25+ years expertise inBiotech Drug Development

Name Placeholder

Co-founder & CCO

Name Placeholder

Driving commercial strategy and strategic partnerships to bring our precision therapeutics to patients globally.

Scientific Advisory Board

V. Asnafi

V. Asnafi

MD, PhD

Head of the Onco-Hematology laboratory and co-directs the "Normal and Pathological Lymphoid Differentiation Team" Institut Necker Enfants Malades

N. Vey

N. Vey

MD, PhD

Managing Director at the Institut Paoli-Calmettes (IPC), Professor of Hematology at Aix-Marseille University

C. Halfon-Domenech

C. Halfon-Domenech

MD, PhD

Head of the Pediatric immunohematology from Institut d’hématologie et d’oncologie pédiatrique (IHOPe)

F. Bellamy

F. Bellamy

PhD

Medicinal Chemistry and Preclinical Development within the pharmaceutical industry and start-up companies

P. Dubreuil

P. Dubreuil

PhD

Doctor in Immunology Recognized expert in signal transduction pathways and kinase biology

favoriteHuman Impact

The Science is Ready

  • check_circleUnmet Need: Targeting refractory pediatric and adult ALL
  • check_circleMode of Action: Metabolic synthetic lethality with high selectivity
  • check_circleBridge-to-Transplant: Inducing rapid, MRD-negative remissions
trending_upFinancial Impact

The Business is Ready

  • check_circleOrphan Strategy: Fast-to-market path for our lead asset (ORT001)
  • check_circleCapital Efficient: Designed for rapid clinical validation and early exit
  • check_circleSecured IP: Exclusive worldwide license (WO 2023/135330A1)

Let's transform the future of Leukemia

Investors, partners, and clinicians — let's build the future of precision oncology together.